Technology Opportunities

High blood cholesterol level is a main and well established risk factor for the development of cardiovascular disease. Statins, inhibitors of cholesterol biosynthesis, are the leading drugs for reducing cholesterol levels and the most prescribed pharmaceuticals worldwide. We have created synthetic molecules, corroles, which are catalytic antioxidants that also effectively inhibit cholesterol biosynthesis. Furthermore, the combination of corroles and statins is highly synergistic, implying such a co-therapy as extremely useful for treating cardiovascular disease and other diseases related to hypercholesterolemia.