Provides method for sustained local delivery of drugs
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Categories |
Animal Science / Veterinary Medicine, Drug Delivery |
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Development Stage |
Formulations tested in dogs, goats, and pigeons; shortly to be tested in cows and zoo animals |
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Patent Status |
United States patent application filed |
Highlights
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Oral administration or multiple dosages of medications in veterinary medicine is often unfeasible.
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There is a need for drug formulations that will provide sustained release of active ingredients over a prolonged period and that can be administered by subcutaneous injection.
Our Innovation
Sustained-release, injectable drug formulation for veterinary applications that enables prolonged treatment after a single administration.
Figure: Graph comparing the plasma concentrations of amoxicillin over time in dogs following injections with the new controlled-release formulation of amoxicillin (amoxi) and a single intra-muscular injection of amoxicillin (Sim); A minimum inhibitory concentration (MIC) of amoxicillin is indicated for comparison. The significant prolongation of the time over MIC is apparent.
Key Features
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A single injection can deliver active ingredients for treatment over a prolonged period
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Reduces the incidence of injection site complications
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Improves drug compliance
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The formulation can include greater amounts of biologically active ingredient than a simple solution
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Sustained-release formulations mitigate the bolus effect at the time of injection, reducing drug side effects
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Reduces the cost of repeated veterinarian visits
Development Milestones
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Seeking industry cooperation to develop formulations for both veterinary purposes and in humans
The Opportunity
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Possible applications for pets, farm animals, animals in zoos, and wild animals
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Also applications for human use
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