There are various conditions in which enhanced bone formation is required to prevent continuing deterioration and damage. The most apparent are bone fractures or bone deficiency, where it would be desirable to stimulate bone growth and to accelerate and complete bone repair. In spite of the enormous efforts to develop an effective, low cost, easy to use and safe bone substitutes, current treatments are dissatisfying regarding success rates, high morbidity and high rehabilitation expenses. Osteoporosis, which affects 20 million people in the US only, is also characterized by deterioration of bone tissue, leading to increased bone fragility and a consequently to increased fracture risk.
The Technology
We have developed novel 3D multifunctional peptide template matrices (PTM) in the form of hydrogels which act as bio-mimetic scaffolds for hydroxylapetite formation and bone tissue regeneration. These matrices accelerate bone formation by actively promoting hydroxylapetite formation in a manner which is cell independent as well as boost osteogenic cell binding and proliferation. Our de-novo bone repair PTM were developed using an interdisciplinary approach that combines rational peptide designing with profound understanding of the hydroxylapetite bio-mineralization and bone formation mechanisms.
We have developed novel 3D multifunctional peptide template matrices (PTM) in the form of hydrogels which act as bio-mimetic scaffolds for hydroxylapetite formation and bone tissue regeneration. These matrices accelerate bone formation by actively promoting hydroxylapetite formation in a manner which is cell independent as well as boost osteogenic cell binding and proliferation. Our de-novo bone repair PTM were developed using an interdisciplinary approach that combines rational peptide designing with profound understanding of the hydroxylapetite bio-mineralization and bone formation mechanisms.
Applications
• Revolutionary local treatment for osteoporosis
• Injectable bone regenerating scaffold and local drug delivery system
• Upgrade of commercially available bone substitutes.
• Revolutionary local treatment for osteoporosis
• Injectable bone regenerating scaffold and local drug delivery system
• Upgrade of commercially available bone substitutes.
Advantages
• Accelerate bone formation
• Can be easily combined with various state of the art complementary products
• Injectable, safe, easy to produce synthetic compounds, which mimic natural regenerative mechanisms.
• Accelerate bone formation
• Can be easily combined with various state of the art complementary products
• Injectable, safe, easy to produce synthetic compounds, which mimic natural regenerative mechanisms.
Development Stage
• Methodology for hydrogel formation at physiologically relevant conditions was developed.
• Cell free hydroxylapetite nucleation was induced on peptide assemblies in 3D hydrogels
• Hydrogels were shown to support adhesion and proliferation of osteogenic cells.
• Hydrogels were shown to be safe in acute toxicity tests.
• In vivo experiment in small animal models are in progress.
• Methodology for hydrogel formation at physiologically relevant conditions was developed.
• Cell free hydroxylapetite nucleation was induced on peptide assemblies in 3D hydrogels
• Hydrogels were shown to support adhesion and proliferation of osteogenic cells.
• Hydrogels were shown to be safe in acute toxicity tests.
• In vivo experiment in small animal models are in progress.
Patent Status
Patent Pending
1586128335.jpg)