| United States Patent | 6,541,454 |
| Breuer , et al. | April 1, 2003 |
Phosphonates, biphosphonates and pharmaceutical compositions containing them
A method for treating patients having calcium related disorders includes using di- or tripeptide derivatives of bisphosphonates to enhance oral bioavailability of such compounds.
| Inventors: | Breuer; Eli (Jerusalem, IL), Golomb; Gershon (Efrat, IL), Amidon; Gordon L. (Ann Arbor, MI), Alferiev; Ivan Sergeievitch (Clementon, NJ), Rozen; Naama El-Hanany (Rehovot, IL), Friedman-Ezra; Aviva (Jerusalem, IL) |
| Assignee: |
Yissum Research Development Company of the Hebrew University Jerusalem (Jerusalem, IL) |
| Appl. No.: | 08/930,676 |
| Filed: | December 31, 1997 |
| PCT Filed: | April 03, 1996 |
| PCT No.: | PCT/US96/04810 |
| PCT Pub. No.: | WO96/31227 |
| PCT Pub. Date: | October 10, 1996 |
1586128900.png)