Technology Opportunities

Mortalin (also known as GRP75 and mitochondrial stress protein 70) is a ubiquitously expressed mitochondrial chaperone related to the cytosolic heat shock protein 70 (HSP70). It protects cells from senescence and apoptosis and is overexpressed in most cancer cells. We discovered that cell ...

TechnologyA novel mode of treatment by inhibition of mortalin or mortalin synthesis as an adjuvant to antibodybased immunotherapy.Novel siRNA was designed as blocker of Mortalin expression. The anti-mortalin siRNA binds specifically to mortalin mRNA and leads to its destruction. Upon ...