Technology Opportunities

THE NEED The resistance to antiviral drugs is the main need for such a technology. Protons entry into the virus via the M2 channel is crucial for fusion of the membranes of the virus and endosome upon viral entry into the host cell. Thus, blocking of the M2 channel inhibits the virus. Indeed, ...

OUTLINE The PAX8 transcription factor is essential for ovarian cancer proliferation, and its silencing in ovarian cancer cells leads to senescence and apoptosis. We propose a novel anti-ovarian cancer therapy based on small molecule binders of PAX8 that stabilize it in a conformation that ...