Technology Opportunities

Even in the presence of oxygen, most cancers rely on glycolysis as the main pathway for generating energy (the Warburg effect) and as a source of precursors for generating proteins, nucleotides and lipids. Such metabolic re-programming of cancer cells includes marked over-expression of the isoforms ...

The voltage-dependent anion channel (VDAC) has been identified as an attractive potential target for modulating cellular energy and apoptosis. VDAC1, located at the outer mitochondrial membrane, mediates the cross-talk between the mitochondria and other parts of the cell by transporting anions, ...