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3D tissue structures using differentiating embryonic stem cells (Technion)
Human embryonic stem (hES) cells hold promise as an unlimited source of cells for transplantation therapies. The present invention is a method for the control of hES cell proliferation and differentiation into complex, viable 3D tissue constructs. The invention describes the use of biodegradable ...
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3D vascularized pancreatic islets - for islets transplantation (Technion)
The present invention provides an advanced tissue-engineering technique for the development of 3D co-culture systems that reconstruct vascularization of pancreatic tissue ex-vivo. In this novel engineered 3D pancreatic model, isolated pancreatic islets can be co-cultured with endothelial cells. The ...
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A new drug and gene delivery system to the brain (Technion)
Though the brain has relatively high blood flow, it remains one of the least accessible organs for drug delivery due to the blood-brain barrier (BBB) and cerebrospinal fluid barrier, which separate the brain from its blood supply and control the movement of compounds in and out of the brain. Our ...
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A novel strategy for treating melanoma development and resistance (Technion)
The present technology describes the caspase-3/YAP module as a new target for the treatment of melanoma development and ...
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Adult stem cell-derived connective tissue progenitors for tissue engineering (Technion)
The present invention provides methods for generating and utilization of connective tissue progenitor cells from adult stem cells, successfully overcoming shortcomings of presently known configurations. Adult stem cells differentiate into connective tissue progenitor cells capable of being ...
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An antibody fragment capable of modulating multidrug resistance (Technion)
The present invention relates to an antibody fragment capable of binding to P-glycoprotein associated with multidrug resistant (MDR) cells. The present invention also relates to compositions and methods utilizing such an antibody fragment for inhibiting drug efflux activity in MDR cancer cells. ...
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Anti-nematode specific treatment based on cells fusion for agricultural use (Technion)
The present technology offers a new approach, using fusogene to treat nematodes infection and overcome the resistance appearance in a specific non-toxic ...
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Antimicrobial peptides and uses thereof (Technion)
A fragment of a virulent peptide named phenol- soluble modulin (PSM) having anti- bacterial ...
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Bacterial capture by resin-linked oligy-acyl-lysines (Technion)
The present technology relates to a method for filtration and concentration of bacterial contaminants from liquid media, by use of oligomers of acylated lysyls (OAKs) in their resin-linked form ...
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Bifunctional antibiotics for targeting rRNA and resistance-causing enzymes (Technion)
Neomycin B is an important antibiotic, commonly used as a food-additive for agricultural purposes. As a result of antibiotic formulations having been used for several decades, resistance to antibiotics has been evolving. The present invention is a Neomycin B that has been modified by the addition ...
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Cancer multidrug resistance diagnostic method for personalize chemotherapy (Technion)
The present technology provides a quick and reliable test to identify multidrug resistance in cancer cells and personalize chemotherapeutic drug treatment. ...
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Casein micelles for encapsulation of hydrophobic compounds (Technion)
The present technology presents a novel harness casein-micelles (CM), which are natural nanocapsules of essential nutrients for the neonate, by incorporating nutraceuticals in their ...
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Casein particles encapsulating therapeutically active agents. (Technion)
The present technology describes a novel oral drug delivery system for drug resistance gastric cancers. Comprising a hydrophobic chemotherapeutic drug and a chemosensitizer entrapped within nanoparticles of beta casein (β-CN), which self-associates into micelles. ...
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Cell-derived liposomes for drug delivery (Technion)
A major challenge facing cancer therapy is achieving specific cytotoxic effect towards cancer cells while sparing the healthy ones. This invention describes the development of an innovative targeted system for cancer therapy based on mesanchymal stem cell (MSC) derived liposomes. The engineered ...
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Compositions and Methods for Diagnosing and Treating an Inflammation (Technion)
A method of treating multiple sclerosis (MS) in a subject in need thereof, the method comprising administering to said subject a therapeutically effective amount of an isolated polypeptide comprising an antigen recognition ...
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Compositions and methods for drug delivery (Technion)
The present invention is of a hydrogel containing an immobilized, naturally-occurring protein drug carrier which may be used for sustained or controlled drug delivery applications. This hydrogel matrix can also be made to be biodegradable. Following this concept, a photopolymerizable hybrid ...
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Compositions comprising semaphorins for the treatment of angiogenesis related diseases and methods of selection thereof (Technion)
A method of selecting a semaphorin for treating cancer in a subject is disclosed. The method comprises determining an expression of a semaphorin receptor on tumor cells of a tumor sample of the subject wherein an ...
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Controlling the reactivity of immune cell populations against cancer (Technion)
Tumor infiltrating lymphocytes (TILs) form immune populations with potential reactivity against melanoma. The degree of reactivity varies considerably among different TIL populations but the underlying network that governs the reactivity is poorly understood. The inventors were able to extract a ...
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Cylindrical probe for ex-situ nuclear magnetic resonance spectroscopy (Technion)
This invention is a new type of ex-situ nuclear magnetic resonance (NMR) probe with spectroscopic capability. NMR, and its descendant, magnetic resonance imaging (MRI) are among the most powerful and versatile analytic and diagnostic methods in science. Current devices suffer from the need to ...
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Deriving extracellular matrix from hES cells and human iPS cells (Technion)
The extracellular matrix (ECM) composition affects the cell attachment, migration, proliferation and 3D arrangement. This new invention uses differentiated human embryonic stem (hES) cells or human induced pluripotent stem cells (iPS) to generate ECM for surgical applications. This new invention ...
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