The general purpose of my research is to describe the genetic and endocrine regulation of bone metabolism. To this end, we developed expertise in most aspects of bone research, from in vivo models, imaging of bone microarchitecture, in vitro cell cultures and molecular biology.
Main Research ...
Animal eye models for evaluation of systemic and topical use of new medications, devices and delivery systems. The models include external eye, intraocular, orbital, and optic nerve ...
This model has been developed in mice and can be applied also to humans. Humans: Specific fatty acids are fed to the mothers during pregnancy and their impact on the lipid profile ,gene expression and metabolism of the offspring can be assessed at birth and different stages of growth under ...
In vitro and in vivo animal models for stroke, Alzheimer's disease (AD), and multiple sclerosis (MS). Rapid screening method for selecting candidates with specific insulin-degrading enzyme inhibitor activity in Types I and II Diabetes.
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Our main focus is on the psychological and neurobiological mechanisms that underlie psychiatric disorders, and in particular addiction
We are using rodent models of addiction, anxiety, learning and memory. We focus on behavioral models relevant to different stages of addiction (craving, drug ...
Tel-Aviv University (TAU) holds several regular and SPF (Specific Pathogen Free) animal care facilities, providing state-of-the-art non-clinical and pre-clinical laboratory research services.
We can perform multi-level studies, using a large variety of animals and supply veterinarian ...
Need:
The market for acne drugs, largely based on 3 drugs and mostly cosmetic in purpose, is >$3B and forecast to grow to >$5B next decade. These numbers may be underestimates based on the psychological impact of disease and reticence to discuss it as well as use of antibiotics that is ...
The ProblemHCV is a major public health problem, with over 185 million people infected worldwide and at risk for developing life-threatening liver disease. Although FDA approved several Direct-Acting Antiviral Drugs (DAAs) demonstrating high efficacy and safety, they are highly expensive and ...
The present technology offers a new approach, using fusogene to treat nematodes infection and overcome the resistance appearance in a specific non-toxic ...
"M2", a novel cysteine constrained looped 14-amino acid peptide, has been developed and optimized to bind HIV gp120. M2 binding allosterically elicits conformational rearrangements in the structure of HIV gp120 revealing the "CD4 induced" co-receptor binding site yet without occluding the ...
Antibodies from mouse lymphoma cells recognize human breast cancer
Categories
Oncology, breast cancer diagnosis and treatment, antibodies
Development Stage
Positive results obtained in mice and in small number of human samples
Patent Status
U.S. patent pending, PCT publication ...
THE NEED The resistance to antiviral drugs is the main need for such a technology. Protons entry into the virus via the M2 channel is crucial for fusion of the membranes of the virus and endosome upon viral entry into the host cell. Thus, blocking of the M2 channel inhibits the virus. Indeed, ...
Need:
Heart failure is a major cause of death and disability in both developed and developing countries. Major clinical conditions associated with heart failure include: 1) End-stage chronic heart failure (including ischemic and non-ischemic cardiomyopathy), 2) Acute decompensated heart ...
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